Harmaline-Induced Tremor in Mice: Videotape Documentation and Open Questions About the Model

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Harmaline-Induced Tremor in Mice: Videotape Documentation and Open Questions About the Model

BACKGROUND Harmaline-induced tremor in rodents has been extensively used as an animal model for essential tremor (ET). However, there is no visual documentation in the published literature. METHODS We injected mice subcutaneously with either 20 mg/kg of harmaline hydrochloride or saline and then videotaped the responses. RESULTS Action and postural tremor in the mouse began 5 minutes after ...

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Riluzole Ameliorates Harmaline-Induced Tremor in Rat

Introduction: Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of current study was to investigate the effects of riluzole on harmaline-induced tremor in rat. Material and Methods: Four groups of Wistar rats weighing 80–100 g were injected with harmaline...

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Effect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice

Objective(s): Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmaline-induced tremor in mice. Materials and Methods: To induce tremor, harma...

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Riluzole Ameliorates Harmaline-induced Tremor in Rat

INTRODUCTION Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of the present study was to investigate the effects of riluzole on harmaline-induced tremor in rat. METHODS Four groups of Wistar rats weighing 80-100 g were injected with harmaline (30 mg/ ...

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riluzole ameliorates harmaline-induced tremor in rat

introduction: excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. we hypothesized that antiglutamatergic agents would suppress harmaline tremor. from this point of view, the aim of current study was to investigate the effects of riluzole on harmaline-induced tremor in rat. material and methods: four groups of wistar rats weighing 80–100 g were injected with harmaline...

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ژورنال

عنوان ژورنال: Tremor and Other Hyperkinetic Movements

سال: 2013

ISSN: 2160-8288

DOI: 10.5334/tohm.139